تفاعل #73904

معادلة التفاعل

5-Bromobenzofuran-2-carboxylic acid

sodium bicarbonate

Selectflor

→

5-Bromo-2-fluoro-1-benzofuran

المذيبات

carbon tetrachloride

dichloromethane

sodium hydroxide

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic phase was separated
2. 2
   غسيلwashed with brine
3. 3
   تجفيفdried over anhydrous MgSO4
4. 4
   أخرىThe solvent was evaporated under reduced pressure at room temperature
5. 5
   غسيلeluted with diethyl ether

الإجراء التجريبي

5-Bromobenzofuran-2-carboxylic acid (4.68 g) was suspended in carbon tetrachloride (150 ml) and water (50 ml). To this was added sodium bicarbonate (3.36 g), followed by Selectflor (7.1 g) and the reaction mixture was stirred rapidly for 20 hours. The reaction mixture was diluted with dichloromethane and 2N sodium hydroxide solution. The organic phase was separated, washed with brine and dried over anhydrous MgSO4. The solvent was evaporated under reduced pressure at room temperature. The residue was applied to a silica cartridge (20 g) and eluted with diethyl ether. This gave 5-bromo-2-fluoro-1-benzofuran (1.4 g).

المصدر