تفاعل #73902

معادلة التفاعل

methyl N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucinate

lithium hydroxide

→

N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucine

المردود 95.8%

المذيبات

methanol

water

ظروف التفاعل

المعالجة

1. 1
   أخرىwas removed in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water (10 ml)
3. 3
   غسيلeluted with water (×2) and methanol (×2)
4. 4
   أخرىevaporated

الإجراء التجريبي

To a solution of methyl N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucinate (520 mg) in methanol (5 ml) was added a solution of lithium hydroxide (91 mg) in water (3 ml). After stirring vigorously for 24 hours the solvent was removed in vacuo. The residue was diluted with water (10 ml) then neutralised with 2N hydrochloric acid. This solution was applied to an Oasis™ cartridge (2×6 g) and eluted with water (×2) and methanol (×2). The required fractions were combined and evaporated to afford N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucine (478 mg).

المصدر