تفاعل #7389

معادلة التفاعل

5-chloro-1-benzofuran-2-carboxylic acid

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title compound

5-Chloro-1-benzofuran

المذيبات

1-methyl-2-pyrrolidinone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction vessel was cooled to room temperature
2. 2
   أخرىthe combined mixtures partitioned between water and diethyl ether
3. 3
   غسيلThe organic layer was washed with water and brine
4. 4
   تجفيفdried (over magnesium sulphate)
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

المصدر