تفاعل #738176

معادلة التفاعل

ethyl 4-acetylbenzoate

bromine

NaHCO3

→

ethyl 4-(2′-bromoacetyl)benzoate

المردود 81.7%

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred for 30 min.
2. 2
   أخرىthe layers are separated
3. 3
   غسيلThe organic layer is washed with NaHCO3, H2O
4. 4
   تجفيفdried over MgSO4
5. 5
   تركيزconcentrated to half of its volume and refrigerated overnight
6. 6
   ترشيحThe resulting solid is filtered

الإجراء التجريبي

To a solution of ethyl 4-acetylbenzoate (5.12 g, 26.6 mmol) in ether (50 ml) containing aluminium chloride (0.025 g, 0.19 mmol) is added bromine (1.31 ml, 26.6 mmol) and the reaction mixture is stirred for 2 h. The reaction mixture is poured into saturated NaHCO3 solution and stirred for 30 min. and the layers are separated. The organic layer is washed with NaHCO3, H2O, dried over MgSO4, concentrated to half of its volume and refrigerated overnight. The resulting solid is filtered to yield ethyl 4-(2′-bromoacetyl)benzoate (5.89 g, 81.6%) as white crystals.

المصدر