تفاعل #73752

معادلة التفاعل

36

1-(2′-(Benzyloxy)-3′-tert-butylbiphenyl-3-yl)ethanone

ortho-methoxyphenyl magnesium bromide

ammonium chloride

→

1-(2′-(Benzyloxy)-3′-tert-butylbiphenyl-3-yl)-1-(2-methoxyphenyl)ethanol

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   استخلاصextracted with ethyl acetate (150 mL)
3. 3
   استخلاصThe organic extract
4. 4
   غسيلwas washed with water (2×50 mL)
5. 5
   تجفيفdried over sodium sulfate
6. 6
   ترشيحfiltered
7. 7
   أخرىThe solvent was removed in a rotary evaporator
8. 8
   أخرىthe crude 37 thus obtained
9. 9
   أخرىwas used in the next step without further purification

الإجراء التجريبي

A solution of 36 (0.8 g, 2.23 mmol) in anhydrous tetrahydrofuran (8 mL) was stirred under nitrogen at room temperature and 1M ortho-methoxyphenyl magnesium bromide in tetrahydrofuran (3 mL, 1.35 equiv.) was slowly added. Stirring was continued at room temperature for 30 min and at 60° C. for 3 hr. After cooling, the reaction mixture was poured on saturated ammonium chloride (120 mL) and extracted with ethyl acetate (150 mL). The organic extract was washed with water (2×50 mL), dried over sodium sulfate and filtered. The solvent was removed in a rotary evaporator and the crude 37 thus obtained was used in the next step without further purification.

المصدر