تفاعل #736429

معادلة التفاعل

compound

N-(N-benzyloxy 2-formamido 3-phenylpropanoyl)-glycine isoamylamide

BuOH AcOH H2O

→

N-(N-hydroxy 2-formamido 3-phenyl propanoyl)-glycine isoamylamide

المذيبات

—

mixture

CH3OH AcOH H2O

ظروف التفاعل

المعالجة

1. 1
   أخرىthe theoretical volume is absorbed
2. 2
   ترشيحfiltered
3. 3
   تركيزconcentrated to dryness
4. 4
   أخرىgiving a white solid

الإجراء التجريبي

127 mg of the compound of Example 31 are dissolved in 3 ml of the mixture CH3OH/AcOH/H2O, 4/5/1 and hydrogenated at ordinary pressure in the presence of 30 mg of 10% Pd/C. After 1 hour, the theoretical volume is absorbed or filtered, and concentrated to dryness giving a white solid. W 88 mg. Rdt 88%; Rf 0.85; BuOH/AcOH/H2O, 4/1/1/.

المصدر