تفاعل #734565

معادلة التفاعل

water

LiAlH4

ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-3-oxopentanoate

hydride

→

4-[4-(4-trifluoromethylphenoxy)phenoxy]-pentane-1,3-diol

المذيبات

ether

ether

ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter addition
2. 2
   ترشيحthe mixture is filtered
3. 3
   تركيزfiltrate concentrated
4. 4
   أخرىThe oily product is purified by prep

الإجراء التجريبي

To a slurry of LiAlH4 (200 mg) in anhydrous ether (15 ml) is added at 0° a solution of ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-3-oxopentanoate(400 mg) in ether (5 ml). After addition is complete, the reaction mixture is stirred at RT for about one hour. Excess of the hydride is decomposed using wet ether and water, the mixture is filtered and filtrate concentrated. The oily product is purified by prep. thin layer chromatography to give 4-[4-(4-trifluoromethylphenoxy)phenoxy]-pentane-1,3-diol, MS m/e 500 (M+).

المصدر