تفاعل #732727

معادلة التفاعل

water

2-fluoro-nicotinonitrile

1-methyl-piperidin-4-ol

NaH

→

title compound

المردود 29.3%

2-(1-Methyl-piperidin-4-Yloxy)-nicotinonitrile

المردود 29.3%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate (2×)
2. 2
   أخرىThe solvent was removed
3. 3
   أخرىthe resulting residue was chromatographed

الإجراء التجريبي

To a mixture of 2-fluoro-nicotinonitrile (400 mg, 3.3 mmol) and 1-methyl-piperidin-4-ol (380 mg, 3.3 mmol) in N,N-dimethylformamide (30 mL) was added NaH (60%) (160 mg, 4.0 mmol) in portions. The reaction was stirred overnight at rt. The mixture was poured into water, and extracted with ethyl acetate (2×). The solvent was removed, and the resulting residue was chromatographed using ethyl acetate/methanol (8:1) to give the title compound (210 mg, 29%). MS (DCI/NH3) m/z 218 (M+1)+

المصدر