تفاعل #7326

معادلة التفاعل

Pyridine

cyanuric fluoride

FMOC-L-Leucine

→

FMOC-L-leucyl fluoride

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe resulting slurry was filtered
2. 2
   workup.ADDITIONThe filtrate was poured into a separatory funnel
3. 3
   أخرىthe layers were separated
4. 4
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

FMOC-L-Leucine (5 g, 14.14 mmol) (Bachem) was dissolved in acetonitrile (70 mL). Pyridine (1.14 mL, 14.14 mmol) (Aldrich) and cyanuric fluoride (1.91 g, 14.14 mmol) (Aldrich) were successively added at room temperature and the mixture was stirred overnight. Ice cold water (300 mL) was added and the resulting slurry was filtered. The filtrate was poured into a separatory funnel and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford FMOC-L-leucyl fluoride as a white powder. (Yield 4.57 g, 91%).

المصدر