تفاعل #73175

ord-e449ac4e97924c6d904b7f0abce4cac4

معادلة التفاعل

CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
Intermediate B
CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
c1ccc2[nH]ccc2c1
indole
→
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc4ccccc43)nc2N1C1CCCC1
title compound
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc4ccccc43)nc2N1C1CCCC1
(R)-8-cyclopentyl-7-ethyl-2-(1H-indol-1-yl)-5-methyl-7,8-dihydropteridin-6(5H)-one

المتفاعلات

CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
Intermediate B
CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
c1ccc2[nH]ccc2c1
indole

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared similarly to the methods described in Example 77, with Intermediate B instead of Intermediate C and with indole instead of 2-phenyl-1H-imidazole. LCMS: 376.2 m/z (M+H)+; ret. Time: 9.10 min (Analytical Method A).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08541418B2uspto-grants-2013_09