تفاعل #73168

ord-e71c86cd3cf9420387d3275af668b893

معادلة التفاعل

CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
Intermediate B
CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
Clc1ncc[nH]1
2-chloro-1H-imidazole
→
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3Cl)nc2N1C1CCCC1
title compound
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3Cl)nc2N1C1CCCC1
(R)-2-(2-chloro-1H-imidazol-1-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

المتفاعلات

CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
Intermediate B
CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CCCC1
(R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
Clc1ncc[nH]1
2-chloro-1H-imidazole

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared similarly to the methods described in Example 185, with Intermediate B instead of Intermediate C and 2-chloro-1H-imidazole instead of 2-(3,5-dichlorophenyl)-1H-imidazole. LCMS: 361.2 m/z (M+H)+; ret. Time 10.06 min (Analytical Method C).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08541418B2uspto-grants-2013_09