تفاعل #731435

معادلة التفاعل

N-(1,3-dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide hydrochloride

6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one

5-amino-1,3-dimethylpyrazole

→

N-(1,3-Dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide

ظروف التفاعل

الإجراء التجريبي

Using methods substantially equivalent to those described in Example 118, N-(1,3-dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 5-amino-1,3-dimethylpyrazole.

المصدر