تفاعل #7313

معادلة التفاعل

1-(5-chlorobenzotriazol-1-yl)-propan-2-one

ethanol

sodium cyanide

ammonium chloride

→

2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile

المذيبات

—

solution

ammonia

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture is subsequently concentrated by evaporation in a vacuum
2. 2
   workup.DISSOLUTIONdissolved again in ethyl acetate
3. 3
   غسيلwashed with water and saturated sodium chloride solution
4. 4
   أخرىThe organic phase is separated
5. 5
   تجفيفdried with magnesium sulphate
6. 6
   تركيزconcentrated by evaporation

الإجراء التجريبي

240 mg of 1-(5-chlorobenzotriazol-1-yl)-propan-2-one are dissolved in 4 ml of a 2-molar solution of ammonia in ethanol, then 64 mg of sodium cyanide and 91 mg of ammonium chloride are added and the mixture is stirred over night at room temperature. The reaction mixture is subsequently concentrated by evaporation in a vacuum, dissolved again in ethyl acetate, and washed with water and saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulphate and concentrated by evaporation. 2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile is thus obtained.

المصدر