تفاعل #73094

معادلة التفاعل

2-(4-(methylthio)phenyl)-4,5-dihydro-1H-imidazole

K2CO3

→

2-(4-(methylthio)phenyl)-1H-imidazole

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with EtOAc
2. 2
   تركيزthe organic layer was concentrated

الإجراء التجريبي

To a solution of 2-(4-(methylthio)phenyl)-4,5-dihydro-1H-imidazole (2-Im-1, 9.6 g, 1.0 eq) in 100 mL of DMSO, DIB (1.1 eq) and K2CO3 (1.1 eq) were added. The mixture was heated to 70° C. overnight, then extracted with EtOAc and the organic layer was concentrated to provide 2-(4-(methylthio)phenyl)-1H-imidazole (compound 3-Im-1).

المصدر