تفاعل #73088

معادلة التفاعل

D-pyroglutamic acid

EtOH

→

(R)-ethyl 5-oxopyrrolidine-2-carboxylate

المذيبات

sulfuric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated
2. 2
   درجة الحرارةunder reflux overnight
3. 3
   أخرىSolvent was removed under reduced pressure

الإجراء التجريبي

To a solution of D-pyroglutamic acid (compound I-A, 20.4 g, 0.16 mol) in 100 mL of EtOH, 1.2 mL of conc. sulfuric acid was added. The mixture was heated under reflux overnight. Solvent was removed under reduced pressure to give (R)-ethyl 5-oxopyrrolidine-2-carboxylate (compound II-AA).

المصدر