تفاعل #73067

معادلة التفاعل

1-methyl-4-nitromethylpiperidin-4-ol

→

4-aminomethyl-1-methylpiperidin-4-ol

المردود 106.3%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 55 hours
2. 2
   ترشيحThe reaction mixture was filtered through a layer of CELITE
3. 3
   ترشيحfilter aid
4. 4
   غسيلthe filter cake was rinsed with methanol (100 mL)
5. 5
   تركيزThe filtrate was concentrated under reduced pressure

الإجراء التجريبي

Palladium hydroxide (2.3 g of 20% on carbon) was added to a solution of 1-methyl-4-nitromethylpiperidin-4-ol (11.57 g) in ethanol (120 mL). The mixture was placed under hydrogen pressure (50 psi, 3.4×105 Pa) on a Parr apparatus for 55 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with methanol (100 mL). The filtrate was concentrated under reduced pressure to provide 10.18 g of 4-aminomethyl-1-methylpiperidin-4-ol as a thick oil.

المصدر