تفاعل #73031

معادلة التفاعل

4-[(3-nitro[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol

→

4-[(3-amino[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol

المردود 115.1%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 3 hours
2. 2
   ترشيحThe reaction mixture was filtered through a layer of CELITE
3. 3
   ترشيحfilter aid
4. 4
   غسيلthe filter cake was rinsed with 1:1 ethyl acetate
5. 5
   تركيزThe filtrate was concentrated under reduced pressure

الإجراء التجريبي

A mixture of 4-[(3-nitro[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol (12.2 g), 5% platinum on carbon (1.22 g), and ethyl acetate (160 mL) was placed under hydrogen pressure (40 psi, 2.8×105 Pa) for 3 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with 1:1 ethyl acetate:methanol (150 mL). The filtrate was concentrated under reduced pressure to provide 12.66 g of 4-[(3-amino[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol as a thick semi-solid.

المصدر