تفاعل #730087

معادلة التفاعل

S-tritylcysteine

2,2,3,3,3-pentafluoropropan-1-ol

DIPEA

triflic anhydride

→

2(R)-(2,2,3,3,3-pentafluoropropylamino)-3-tritylsulfanylpropionic acid

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction mixture was stirred at RT for 18 h
2. 2
   تركيزconcentrated on the rotovap
3. 3
   workup.ADDITIONEthyl acetate was added
4. 4
   غسيلthe reaction mixture was washed with 1N HCl
5. 5
   تجفيفThe organic layer was dried over magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated
8. 8
   أخرىThe crude product was purified by flash chromatography (3 hexanes/1 ethyl acetate+1% acetic acid)

الإجراء التجريبي

To a −78° C. methylene chloride solution (75 mL) of 2,2,3,3,3-pentafluoropropan-1-ol (1.5 g, 10.0 mmol) and DIPEA (6.1 mL, 35.0 mmol) was added triflic anhydride (1.78 mL, 10.5 mmol). After 2.5 h, S-tritylcysteine was added all at once and the reaction mixture was stirred at 0° C. for 80 min. The reaction mixture was stirred at RT for 18 h and then concentrated on the rotovap. Ethyl acetate was added and the reaction mixture was washed with 1N HCl. The organic layer was dried over magnesium sulfate, filtered and concentrated. The crude product was purified by flash chromatography (3 hexanes/1 ethyl acetate+1% acetic acid) to provide 2(R)-(2,2,3,3,3-pentafluoropropylamino)-3-tritylsulfanylpropionic acid (3.29 g).

المصدر