تفاعل #72925

معادلة التفاعل

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

المردود 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

المردود 92.0%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was then filtered on celite
2. 2
   أخرىthe filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   غسيلwashed with aqueous NaHCO3
5. 5
   تجفيفThe solvent was dried over sodium sulfate
6. 6
   أخرىremoved under reduced pressure
7. 7
   أخرىto give

الإجراء التجريبي

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

المصدر