تفاعل #72924

معادلة التفاعل

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

المردود 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

المردود 83.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting solution was refluxed for 6 hours
2. 2
   أخرىThe solvent was then removed in vacuo
3. 3
   أخرىthe residue partitioned between dichloromethane and water
4. 4
   تجفيفThe organic layer was dried over sodium sulfate
5. 5
   أخرىevaporated to dryness

الإجراء التجريبي

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

المصدر