تفاعل #728442

معادلة التفاعل

4-hydroxy-3-nitro-benzoic acid methyl ester

→

3-amino-4-hydroxy-benzoic acid methyl ester

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe flask was evacuated
2. 2
   ترشيح45′, the palladium was filtered off
3. 3
   غسيلwashing extensively with ethanol
4. 4
   أخرىThe solvent was removed in vacuo

الإجراء التجريبي

A solution of 4-hydroxy-3-nitro-benzoic acid methyl ester (5.0 g, 25.4 mmol) in ethanol (120 mL) was treated with 5% palladium on active carbon (0.24 g, 2.3 mmol, 0.1 equiv.) and the flask was evacuated and placed under an hydrogen atmosphere. The mixture was stirred vigorously for 2 h and 45′, the palladium was filtered off, washing extensively with ethanol. The solvent was removed in vacuo to yield 3-amino-4-hydroxy-benzoic acid methyl ester as a white solid, 4.2 g (100%), MS (ISP): m/e=168.3 (M+H+). This was used crude in the following reaction.

المصدر