تفاعل #7281

معادلة التفاعل

4-hydroxymethyl-benzaldehyde

2-aminopyridine

acetic acid

sodium triacetoxyborohydride

→

title compound

المردود 74.0%

[4-(Pyridin-2-ylaminomethyl)-phenyl]-methanol

المردود 74.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىone hour at 50° C., followed by purification of crude material

الإجراء التجريبي

Using general procedure B: Reaction of 4-hydroxymethyl-benzaldehyde (1.01 g, 7.42 mmol), 2-aminopyridine (697 mg, 7.42 mmol), acetic acid (0.5 mL) and sodium triacetoxyborohydride (3.2 g, 14.8 mmol) in THF (20 mL) at room temperature under N2 for 40 min., then one hour at 50° C., followed by purification of crude material using chromatography on silica gel (2:2:96 CH3OH—NH3 H2O—CH2Cl2), afforded the title compound (1.17 g, 74%) as white foam.

المصدر