تفاعل #72733

معادلة التفاعل

5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]oct-3-ene

→

5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane

المردود 71.3%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction medium is filtered through diatomaceous earth
2. 2
   أخرىthe solvent is removed by evaporation under reduced pressure
3. 3
   أخرىThe residue obtained
4. 4
   أخرىis purified by chromatography on a column of silica gel
5. 5
   غسيلeluting with a mixture of chloroform, methanol and aqueous ammonia in 95/5/0.5 proportions

الإجراء التجريبي

1.95 g (7.354 mmol) of 5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]oct-3-ene (WO 03/057 697) are introduced into 40 ml of methanol in a hydrogenation flask, and 195 mg of platinum oxide are then placed in suspension. The medium is stirred at room temperature under a hydrogen pressure of 26 psi for 45 minutes. The reaction medium is filtered through diatomaceous earth and the solvent is removed by evaporation under reduced pressure. The residue obtained is purified by chromatography on a column of silica gel, eluting with a mixture of chloroform, methanol and aqueous ammonia in 95/5/0.5 proportions. 1.4 g of 5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane are obtained in the form of a waxy oil.

المصدر