تفاعل #72638

معادلة التفاعل

2-cyanoaniline

sulfamide

DBU

→

title compound

1H-Benzo[c][1,2,6]thiadiazin-4-amine-2,2-dioxide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling to room temperature
2. 2
   استخلاصextracted three times with EtOAc
3. 3
   أخرىThe aqueous layer was removed under vacuum
4. 4
   أخرىthe residue was purified by chromatography on silica gel eluting with 10% MeOH in dichloromethane

الإجراء التجريبي

A stirred mixture of 2-cyanoaniline (236 mg, 2.0 mmol), sulfamide (192 mg, 2.0 mmol) and DBU (304 mg, 2.0 mmol) was heated at 160° C. under nitrogen for 3 days. After cooling to room temperature, the reaction mixture was diluted with water and extracted three times with EtOAc. The aqueous layer was removed under vacuum and the residue was purified by chromatography on silica gel eluting with 10% MeOH in dichloromethane to give the title compound as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6) δ7.03 (dd, J=0.8, 8.0 Hz, 1H), 7.12 (dt, J=0.8, 8.0 Hz, 1H), 7.56 (dt, J=0.8, 8.0 Hz, 1H), 7.85 (dd, J=0.8, 8.0 Hz, 1H). MS 198 (MH+).

المصدر