تفاعل #725904

معادلة التفاعل

2-(4-Aminophenoxy)propionic acid methyl ester

2-(4-Amino-phenoxy)-propionic acid methyl ester

triethylamine

triphosgene

→

32

المردود 143.8%

2-(4-Isocyanato-phenoxy)-propionic acid methyl ester

المردود 143.8%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةmaintained at this temp
2. 2
   درجة الحرارةThe reaction mixture was cooled to room temperature
3. 3
   ترشيحthe solids were filtered off
4. 4
   workup.DISTILLATIONthe toluene was distilled off under vacuum
5. 5
   أخرىto get crude 32, which
6. 6
   workup.DISTILLATIONdistilled

الإجراء التجريبي

To a mixture of 2-(4-Aminophenoxy)propionic acid methyl ester 18 (15 grams, 76.9 mmol) and triethylamine (15.6 g, 154.16 mmol) in toluene (210 ml) under nitrogen atm. was added triphosgene (8.4 g, 28.3 mmol) in one lot. Later the reaction mixture was heated to 75° C. over a period of one hour and maintained at this temp. for 26 hours. The reaction mixture was cooled to room temperature, the solids were filtered off, and the toluene was distilled off under vacuum to get crude 32, which was vacuum distilled to get pure 32 (9 g, 52.9%) as a light yellow syrup.

المصدر