تفاعل #725903

معادلة التفاعل

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

(4-Isocyanato-phenoxy)-acetic acid methyl ester

→

30

المردود 56.5%

{4-[2-(4-Methoxycarbonylmethoxy-phenylcarbamoyloxy)-ethoxycarbonylamino]-phenoxy}-acetic acid methyl ester

المردود 56.5%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONToluene was distilled off
2. 2
   workup.ADDITIONwater (10 ml) was added
3. 3
   استخلاصCrude 30 was extracted into chloroform
4. 4
   تجفيفdried over sodium sulphate
5. 5
   workup.DISTILLATIONdistilled
6. 6
   أخرىpurified by column chromatography on silica gel

الإجراء التجريبي

To [4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester 29 (1 g, 3.72 mmol) in toluene (10 ml) was added (4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (0.8 g, 3.8 mmol) at room temperature and heated to 50° C. for 20 hours. Toluene was distilled off and water (10 ml) was added. Crude 30 was extracted into chloroform, dried over sodium sulphate, distilled and purified by column chromatography on silica gel using chloroform as eluant to get pure 30 (1 g, 56.5%) as a white fluffy powder.

المصدر