تفاعل #725891

معادلة التفاعل

2-(4-Acetylaminophenoxy)propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

17

المردود 98.1%

2-(4-Amino-phenoxy)-propionic acid

المردود 98.1%

المذيبات

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   ترشيحfiltered hot
4. 4
   ترشيحfiltered
5. 5
   أخرىdried

الإجراء التجريبي

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

المصدر