تفاعل #725664

معادلة التفاعل

4-(2-nitro-4-trifluoromethylphenoxy)phenol

ethyl 4-bromo-3-methoxy-2-pentenoate

K2CO3

→

ethyl 4-[4-(2-nitro-4-fluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoate

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 24 hours
2. 2
   ترشيحAfter filtration
3. 3
   تركيزthe filtrate is concentrated
4. 4
   أخرىthe oily residue chromatographed on silica gel

الإجراء التجريبي

A mixture of 4-(2-nitro-4-trifluoromethylphenoxy)phenol (9.36 mm), ethyl 4-bromo-3-methoxy-2-pentenoate (12 mm.) and K2CO3 (14 mm.) in acetone (20 ml.) is refluxed for 24 hours. After filtration, the filtrate is concentrated and the oily residue chromatographed on silica gel to yield ethyl 4-[4-(2-nitro-4-fluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoate.

المصدر