تفاعل #72407

ord-27e97dd5f81c4864a82e99c54caa86b2

معادلة التفاعل

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C
docetaxel
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C
docetaxel
→
CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Docetaxel Mannitol

المتفاعلات

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C
docetaxel
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C
docetaxel

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Lyophilization is performed to yield vials containing lyophilized cake comprising docetaxel and mannitol in a ratio of 1:1.5 to 1:3, preferably 1:1.8 to 1:2.7, more preferably 1:2.0 to 1:2.5, and most preferably 1:2.2. The amount of cake may vary, for example a 1:2.2 ratio may be obtained by a vial comprising 20 mg docetaxel and 44 mg mannitol, a vial comprising 80 mg docetaxel and 176 mg mannitol, or a vial comprising 120 mg docetaxel and 264 mg mannitol.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08541360B2uspto-grants-2013_09