تفاعل #723395

ord-a2f881a9d65540f2a4378d847e4578d6

معادلة التفاعل

C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O
N-(3-nitrophenylacetyl)-L-alanine
CCC[C@H](N)C(=O)OC.Cl
methyl (S)-2-aminopentanoate hydrochloride
→
CCC[C@H](NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)OC
title compound
CCC[C@H](NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)OC
Methyl N-[N- (3-nitrophenylacetyl)-L-alaninyl]-(S)-2-aminopentanoate

المتفاعلات

C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O
N-(3-nitrophenylacetyl)-L-alanine
CCC[C@H](N)C(=O)OC.Cl
methyl (S)-2-aminopentanoate hydrochloride

الكواشف

لا شيء

المذيبات

CO.ClC(Cl)Cl
CHCl3 MeOH

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (from Example D11 above) and methyl (S)-2-aminopentanoate hydrochloride (prepared from (S)-2-aminopentanoic acid (Novabiochem) using General Procedure H), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.4 in 9:1 CHCl3/MeOH).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06191166B1uspto-grants-2001_02