تفاعل #723378

ord-aafc18ec16c74cd3963da7ee5414cbe7

معادلة التفاعل

C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O
N-(3-nitrophenylacetyl)-L-alanine
CCOC(=O)[C@@H](N)Cc1ccc(O)cc1
L-tyrosine ethyl ester
→
CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1
title compound
CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1
N-[N-(3-Nitrophenylacetyl)-L-alaninyl]-L-tyrosine Ethyl Ester

المتفاعلات

C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O
N-(3-nitrophenylacetyl)-L-alanine
CCOC(=O)[C@@H](N)Cc1ccc(O)cc1
L-tyrosine ethyl ester
—
solid

الكواشف

لا شيء

المذيبات

CCOC(C)=O
EtOAc

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىthe product was purified by silica gel chromatography

الإجراء التجريبي

Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (prepared from 3-nitrophenylacetic acid (Aldrich) and L-alanine ethyl ester hydrochloride (Sigma) using General Procedure C, followed by hydrolysis using General Procedure AF) and L-tyrosine ethyl ester (Sigma), the title compound was prepared as a solid (mp=117-119° C.). The reaction was monitored by tlc (Rf=0.5 in EtOAc) and the product was purified by silica gel chromatography using EtOAc as the eluent.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06191166B1uspto-grants-2001_02