تفاعل #723045

معادلة التفاعل

LiAlH4

7-fluoroimidazo[2,1-b]benzothiazole-3-carboxylic acid ethyl ester

2-amino-methylbenzothiazole

→

7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىat 0°
2. 2
   أخرىreacted at 25° for one hour
3. 3
   أخرىThe suspension was quenched by serial addition of water and 15% sodium hydroxide
4. 4
   ترشيحThe suspension was filtered
5. 5
   أخرىthe filtrate was evaporated
6. 6
   أخرىto yield crude 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) (1.59 g)
7. 7
   أخرىCrystallization of crude 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) from acetonitrile

الإجراء التجريبي

A solution of 7-fluoroimidazo[2,1-b]benzothiazole-3-carboxylic acid ethyl ester, (synthesized from 2-amino-methylbenzothiazole according to a modification of the procedures described by Fajeli et al., Heterocycles, 1986, 24, 379) (1.93 g) in dry THF (50 mL) at 0° was treated with LiAlH4 (0.36 g) and reacted at 25° for one hour. The suspension was quenched by serial addition of water and 15% sodium hydroxide. The suspension was filtered and the filtrate was evaporated to yield crude 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) (1.59 g). Crystallization of crude 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) from acetonitrile gave pure 7-Fluoro-imidazo[2,1-b]benzothiazole-3-methanol (Formula L-2) (1.3 g), m.p. 240-241°.

المصدر