تفاعل #722701

معادلة التفاعل

3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine

2-chloro-5-chloromethyl-thiazole

potassium carbonate

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title compound

المردود 67.0%

5-(2-Chlorothiazol-5-ylmethyl)-3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine

المردود 67.0%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated for 5 h at 60°
2. 2
   ترشيحfiltered
3. 3
   أخرىThe filtrate is evaporated in vacuo on a rotary evaporator
4. 4
   أخرىthe residue is purified by chromatography [silica gel; dichloromethane/methanol (95:5)]

الإجراء التجريبي

A mixture of 1.62 g of 3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine, 2.44 g of 2-chloro-5-chloromethyl-thiazole, 4.2 g of potassium carbonate and 25 ml of N,N-dimethylformamide is heated for 5 h at 60° and then filtered. The filtrate is evaporated in vacuo on a rotary evaporator, and the residue is purified by chromatography [silica gel; dichloromethane/methanol (95:5)]. This gives the title compound, which melts at 132-134°, in a yield of 67%.

المصدر