تفاعل #72217

معادلة التفاعل

1-hydroxybenzotriazole

ethyl 2-(5-amino-4,5,6,7-tetrahydro-1H-indazol-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

N-methylmorpholine

WSC hydrochloride

→

title compound

المردود 89.1%

Ethyl 2-(5-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1H-indazol-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

المردود 89.1%

ظروف التفاعل

الإجراء التجريبي

The same operation as in Example (217c) was performed using ethyl 2-(5-amino-4,5,6,7-tetrahydro-1H-indazol-1-yl)-4-methyl-1,3-thiazole-5-carboxylate obtained in Example (242d) (50 mg, 0.16 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (28 mg, 0.16 mmol), WSC hydrochloride (94 mg, 0.49 mmol), 1-hydroxybenzotriazole (22 mg, 0.16 mmol) and N-methylmorpholine (0.04 mL, 0.33 mmol), to obtain 66 mg of the title compound as a white solid (88%).

المصدر