تفاعل #72158

معادلة التفاعل

3-tert-butoxycarbonylaminoazetidine

ethyl 2-bromo-4-n-butyl-1,3-thiazole-5-carboxylate

Ethyl 2-bromo-4-n-butyl-1,3-thiazole-5-carboxylate

diisopropylethylamine

→

title compound

المردود 74.4%

Ethyl 2-{3-[(tert-butoxycarbonyl)amino]azetidin-1-yl)-4-n-butyl-1,3-thiazole-5-carboxylate

المردود 74.4%

ظروف التفاعل

الإجراء التجريبي

The same operation as in Example (217a) was performed using 3-tert-butoxycarbonylaminoazetidine (212 mg, 1.23 mmol), ethyl 2-bromo-4-n-butyl-1,3-thiazole-5-carboxylate obtained in Example (220b) (300 mg, 1.03 mmol) and diisopropylethylamine (0.36 mL, 2.06 mmol), to obtain 294 mg of the title compound as a white solid (74%).

المصدر