تفاعل #72148

معادلة التفاعل

sodium carbonate

tert-butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-[(1-ethylpropyl)amino]piperidine-1-carboxylate

hydrochloric acid 1,4-dioxane

ethyl 2-bromo-1,3-benzothiazole-7-carboxylate

→

title compound

المردود 18.1%

Ethyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-[(1-ethylpropyl)amino]piperidin-1-yl)-1,3-benzothiazole-7-carboxylate

المردود 18.1%

ظروف التفاعل

الإجراء التجريبي

The same operation as in Example (196c) was performed using tert-butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-[(1-ethylpropyl)amino]piperidine-1-carboxylate obtained in Example (215a) (49.0 mg, 0.111 mmol), 4 N hydrochloric acid/1,4-dioxane (2 mL), ethyl 2-bromo-1,3-benzothiazole-7-carboxylate obtained in Example (1f) (35 mg, 0.122 mmol) and sodium carbonate (118 mg, 1.11 mmol), to obtain 11 mg of the title compound (18%) as a pale yellow oily substance.

المصدر