تفاعل #721036

ord-bd448303948f426db77cafce8954f7a5

معادلة التفاعل

COc1ccc2ncc3c(c2c1F)CC(C[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CO1)O3
(3R,6S)-[6-(9-fluoro-8-methoxy-1,2-dihydro-furo[2,3-c]quinolin-2-ylmethyl)-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester
O=C1CSc2ccc(C(=O)O)cc2N1
3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid
→
COc1ccc2ncc3c(c2c1F)CC(C[C@@H]1CC[C@@H](NC(=O)c2ccc4c(c2)NC(=O)CS4)CO1)O3
titled compound
COc1ccc2ncc3c(c2c1F)CC(C[C@@H]1CC[C@@H](NC(=O)c2ccc4c(c2)NC(=O)CS4)CO1)O3
3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid (3R,6S)-[6-(9-fluoro-8-methoxy-1,2-dihydro-furo[2,3-c]quinolin-2-ylmethyl)-tetrahydro-pyran-3-yl]-amide

المتفاعلات

COc1ccc2ncc3c(c2c1F)CC(C[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CO1)O3
(3R,6S)-[6-(9-fluoro-8-methoxy-1,2-dihydro-furo[2,3-c]quinolin-2-ylmethyl)-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester
O=C1CSc2ccc(C(=O)O)cc2N1
3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The titled compound is prepared as an off-white lyophilized powder following Scheme 3 and in analogy to Example 13 using (3R,6S)-[6-(9-fluoro-8-methoxy-1,2-dihydro-furo[2,3-c]quinolin-2-ylmethyl)-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09321788B2uspto-grants-2016_04