تفاعل #72075

معادلة التفاعل

2,4-Dinitrobenzonitrile

Potassium carbonate

ethyl thioglycolate

→

title compound

المردود 32.4%

Ethyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate

المردود 32.4%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   غسيلwashed with water
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   تركيزconcentration under reduced pressure
6. 6
   أخرىthe residue was recrystallized from ethyl acetate/hexane

الإجراء التجريبي

2,4-Dinitrobenzonitrile (5.08 g, 26.3 mmol) was dissolved in DMF (55 ml). Potassium carbonate (4.36 g, 31.6 mmol) and ethyl thioglycolate (3.17 g, 26.3 mmol) were added, and the mixture was stirred at room temperature for three days. The reaction solution was concentrated under reduced pressure, diluted with ethyl acetate, washed with water, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was recrystallized from ethyl acetate/hexane to obtain 2.27 g of the title compound as crystals (32%).

المصدر