تفاعل #72033

معادلة التفاعل

cesium carbonate

benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride

ethyl 5-bromopyridine-3-carboxylate

BINAP

→

title compound

المردود 51.2%

Ethyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate

المردود 51.2%

ظروف التفاعل

الإجراء التجريبي

The same operation as in Example (160b) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (832 mg, 2.76 mmol), ethyl 5-bromopyridine-3-carboxylate (530 mg, 2.3 mmol), palladium acetate (51.72 mg, 0.23 mmol), BINAP (286.89 mg, 0.46 mmol), and cesium carbonate (2.25 g, 6.91 mmol), to obtain 487 mg of the title compound as a yellow oily substance.

المصدر