تفاعل #71888

معادلة التفاعل

N-(3-methoxy-4-nitrobenzoyl)threonine methyl ester

N-(3-Methoxy-4-nitrobenzoyl)threonine methyl ester

Burgess reagent

→

title compound

المردود 85.0%

Methyl 2-(3-methoxy-4-nitrophenyl)-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylate

المردود 85.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىPurification
2. 2
   غسيلby silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1, 1/2)

الإجراء التجريبي

The same operation as in Example (97b) was performed using N-(3-methoxy-4-nitrobenzoyl)threonine methyl ester obtained in Example (105a) (4.49 g, 14.4 mmol), the Burgess reagent (3.94 g, 16.5 mmol) and THF (50 mL). Purification by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1, 1/2) gave 3.6 g of the title compound as a light yellow solid (85%).

المصدر