تفاعل #71872

معادلة التفاعل

serine methyl ester hydrochloride

3-methoxy-4-nitrobenzoic acid

WSC hydrochloride

N,N-diisopropylethylamine

→

title compound

المردود 69.0%

N-(3-Methoxy-4-nitrobenzoyl)serine methyl ester

المردود 69.0%

المذيبات

Dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction solution was washed with water and brine
2. 2
   تجفيفdried over anhydrous magnesium sulfate
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىThe residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/2, 1/1, 2/1, 1/0)

الإجراء التجريبي

Dichloromethane (80 mL) was added to serine methyl ester hydrochloride (2.64 g, 17 mmol), 3-methoxy-4-nitrobenzoic acid (3 g, 15.2 mmol), WSC hydrochloride (3.83 g, 20 mmol), DMAP (0.18 g, 1.5 mmol) and N,N-diisopropylethylamine (2.58 g, 20 mmol), and the mixture was stirred at room temperature for one day. The reaction solution was washed with water and brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/2, 1/1, 2/1, 1/0) to obtain 3.11 g of the title compound as a colorless solid (69%).

المصدر