تفاعل #71853

معادلة التفاعل

Burgess reagent

N-(4-nitrobenzoyl)threonine methyl ester

N-(4-Nitrobenzoyl)threonine methyl ester

→

title compound

المردود 133.7%

Methyl 5-methyl-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

المردود 133.7%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction solution was concentrated under reduced pressure
2. 2
   أخرىthe residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1, 1/2)

الإجراء التجريبي

The Burgess reagent (0.60 g, 2.5 mmol) was added to a solution of N-(4-nitrobenzoyl)threonine methyl ester obtained in Example (97a) (0.57 g, 3 mmol) in THF (20 mL), and the mixture was stirred at 60° C. for two hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1, 1/2) to obtain 1.06 g of the title compound as a colorless solid (100%).

المصدر