تفاعل #71824

معادلة التفاعل

sodium (triacetoxy)borohydride

ethyl cis(±)-2-(3-amino-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-benzothiazole-7-carboxylate

Example ( 81e )

Ethyl cis(±)-2-(3-amino-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-benzothiazole-7-carboxylate

1-hexanal

→

title compound

Ethyl cis(±)-2-[4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(hexylamino)piperidin-1-yl]-1,3-benzothiazole-7-carboxylate

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained by the method

الإجراء التجريبي

The same operation as in Example (77d) was performed using ethyl cis(±)-2-(3-amino-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-benzothiazole-7-carboxylate obtained by the method described in Example (81e) (30 mg, 0.063 mmol), 1-hexanal (22 μl, 0.18 mmol) and sodium (triacetoxy)borohydride (175 mg, 0.83 mmol), to obtain 28.4 mg of the title compound as a colorless oily substance (80%).

المصدر