تفاعل #71782

معادلة التفاعل

WSC hydrochloride

tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

HOBT

Example ( 1d )

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid

→

title compound

المردود 72.0%

tert-Butyl (3S,4R)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

المردود 72.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىsynthesized by the method

الإجراء التجريبي

The same operation as in Example (1g) was performed using tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate obtained in Example (56a) (224.4 mg, 0.96 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid synthesized by the method described in Example (1d) (140 mg, 0.80 mmol), WSC hydrochloride (440 mg, 2.29 mmol) and HOBT (110 mg, 0.81 mmol), to obtain 222.4 mg of the title compound as a white solid (72%).

المصدر