تفاعل #71748

معادلة التفاعل

WSC hydrochloride

tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

Example ( 1e )

tert-Butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

HOBT

5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid

5-Methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid

→

title compound

tert-Butyl cis(±)-4-{[(5-methyl-4-trifluoromethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained by the method

الإجراء التجريبي

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (0.22 g, 0.96 mmol), 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid obtained in Example (36d) (0.10 g, 0.51 mmol), WSC hydrochloride (0.30 g, 1.57 mmol) and HOBT (70 mg, 0.52 mmol), to obtain 0.17 g of the title compound as a white foamy substance (83%).

المصدر