تفاعل #71745

معادلة التفاعل

2,2,2-Trifluoro-1-(2-methyl-1,3-dithian-2-yl)ethanone

dimethoxyacetaldehyde

ammonia

NCS

→

2-(Dimethoxymethyl)-5-methyl-4-(trifluoromethyl)-1H-imidazole

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONdistilled water (10 mL)
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 18 hours
3. 3
   ترشيحThe reaction solution was filtered through celite
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   أخرىThe resulting compound was used for the next reaction without purification

الإجراء التجريبي

NCS (870 mg, 6.51 mmol) and silver nitrate (1.48 g, 8.71 mmol) were dissolved in acetonitrile (40 mL) and distilled water (10 mL). 2,2,2-Trifluoro-1-(2-methyl-1,3-dithian-2-yl)ethanone obtained in Example (36a) (500 mg, 2.17 mmol) was added, and the mixture was stirred for 40 minutes. Thereafter, dimethoxyacetaldehyde (5.76 M aqueous solution, 0.4 mL, 23.0 mmol) and 28% aqueous ammonia (2 mL) were added, and the mixture was stirred at room temperature for 18 hours. The reaction solution was filtered through celite and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

المصدر