تفاعل #716146

معادلة التفاعل

2-methyl-6-(methyloxy)-4H-3,1-benzoxazin-4-one

4-chlorophenylmagnesium bromide

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title compound

[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

المذيبات

toluene ether

ظروف التفاعل

المعالجة

1. 1
   أخرىat 0° C.
2. 2
   أخرىbefore being quenched with 1N HCl (200 ml)
3. 3
   استخلاصThe aqueous layer was extracted with EtOAc (3×150 ml)
4. 4
   غسيلthe combined organics were washed with brine (100 ml)
5. 5
   تجفيفdried over Na2SO4
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated under reduced pressure
8. 8
   workup.DISSOLUTIONThe crude compound was then dissolved in ethanol (400 ml)
9. 9
   workup.ADDITION6N HCl (160 ml) was added
10. 10
    درجة الحرارةThe reaction mixture was refluxed for 2 h
11. 11
    تركيزbefore being concentrated to one-third in volume
12. 12
    ترشيحThe resulting solid was filtered
13. 13
    غسيلwashed twice with ether
14. 14
    استخلاصThe aqueous layer was extracted with EtOAc (3×150 ml)
15. 15
    غسيلthe combined organics were washed with brine (150 ml)
16. 16
    تجفيفdried over Na2SO4
17. 17
    ترشيحfiltered
18. 18
    تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of 2-methyl-6-(methyloxy)-4H-3,1-benzoxazin-4-one (for a preparation see Reference compound A) (40.0 g, 0.21 mol) in a toluene/ether (2/1) mixture (760 ml) at 0° C. was added dropwise a solution of 4-chlorophenylmagnesium bromide (170 ml, 1M in diethyl ether, 0.17 mol). The reaction mixture was allowed to warm to room temperature and stirred for 1 h before being quenched with 1N HCl (200 ml). The aqueous layer was extracted with EtOAc (3×150 ml) and the combined organics were washed with brine (100 ml), dried over Na2SO4, filtered and concentrated under reduced pressure. The crude compound was then dissolved in ethanol (400 ml) and 6N HCl (160 ml) was added. The reaction mixture was refluxed for 2 h before being concentrated to one-third in volume. The resulting solid was filtered and washed twice with ether before being suspended in EtOAc and neutralised with 1N sodium hydroxide. The aqueous layer was extracted with EtOAc (3×150 ml) and the combined organics were washed with brine (150 ml), dried over Na2SO4, filtered and concentrated under reduced pressure. The title compound was obtained as a yellow solid (39 g, 88% yield) LC/MS (Method D): m/z 262 [M+H]+, Rt 2.57 min.

المصدر