تفاعل #7156

معادلة التفاعل

ethyl acetate

6-Nitroindole

benzyl chloride

potassium hydroxide

→

N-benzyl-6-nitroindole

المردود 90.0%

المذيبات

dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   غسيلthe organic layer is washed with water
2. 2
   تجفيفdried over sodium sulfate
3. 3
   أخرىthe solvent is evaporated under reduced pressure
4. 4
   أخرىThe residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)

الإجراء التجريبي

6-Nitroindole (1.0 g) and benzyl chloride (2.2 g) are dissolved in dimethylsulfoxide (10 ml), and thereto is added potassium hydroxide (1.0 g), and the mixture is stirred at room temperature for 12 hours. To the mixture is added ethyl acetate, and the organic layer is washed with water, dried over sodium sulfate, and the solvent is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give N-benzyl-6-nitroindole (1.4 g).

المصدر