تفاعل #71558

معادلة التفاعل

4-nitrophenol

triethylamine

ethyl acetate

water

→

butyl 4-nitrophenyl carbonate

المذيبات

tetrahydrofuran

butyl chloroformate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder cooling on ice
2. 2
   أخرىThe organic layer was separated
3. 3
   غسيلwashed with a saturated sodium chloride aqueous solution
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   أخرىAfter removing the solvent
6. 6
   أخرىby evaporation under reduced pressure

الإجراء التجريبي

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

المصدر