تفاعل #71474

معادلة التفاعل

Benzyl chloride

2-nitroimidazole

triethylamine

→

title compound

المردود 50.4%

1-Benzyl-2-nitro-1H-imidazole

المردود 50.4%

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 72 h
2. 2
   غسيلwashed with H2O and brine
3. 3
   تجفيفdried (sodium sulfate)
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated
6. 6
   أخرىThe residue was purified by silica gel column chromatography (Hex/EtOAc, 7:3)

الإجراء التجريبي

Benzyl chloride (1.8 mL, 15.4 mmol, 1.2 equiv) was added to a solution of 2-nitroimidazole (1.45 g, 12.8 mmol) and triethylamine (3.6 mL, 25.7 mmol, 2 equiv) in DCM (40 mL). The reaction mixture was stirred at reflux for 72 h, allowed to cool to rt, diluted with DCM, washed with H2O and brine, dried (sodium sulfate), filtered and concentrated. The residue was purified by silica gel column chromatography (Hex/EtOAc, 7:3) to afford 1.31 g of the title compound as a white solid: ES-MS: 204.0 [M+H]+; tR=3.72 min (System 1); TLC: Rf=0.22 (Hex/EtOAc, 7:3).

المصدر